Androgen Receptor Gene CAG Repeat Polymorphism Regulates the Metabolic Effects of Testosterone Replacement Therapy in Male Postsurgical Hypogonadotropic Hypogonadism

Table 2

Metabolic profile of subjects studied in the two phases.

	Time 0	Recovery phase	Δ	𝑃^+++
Weight (kg)	79.8±10.4	77.8±10.9	−1.9±2.0	0.002
Waist (cm)	95.7±10.3	93.7±9.7	−2.0±1.4	<0.001
Glycaemia (mg/dL)	113.5±12.0	105.6±7.4	−7.8±6.8	<0.001
HbA1C (%)	6.0±0.1	5.9±0.2	−0.1±0.1	<0.001
Total cholesterol (mg/dL)	254.8±39.8	236.6±30.0	−18.1±14.3	<0.001
HDL cholesterol (mg/dL)	39.8±10.5	45.0±6.1	5.2±7.4	0.017
LDL cholesterol (mg/dL)	181 (138–226.6)	149 (131.4–188.4)	−16.6 ((−36)–(−4))	0.001
Triglycerides (mg/dL)	169.4±29.2	159.4±28.3	−10.0±7.10	<0.001
HOMA-IR	9.7±3.2	6.4±1.8	−3.2±1.9	<0.001
SBP (mmHg)	130 (120–140)	120 (110–130)	−10 ((−20)–(−10))	0.002
DBP (mmHg)	89.6±7.8	83.0±5.6	−6.6±6.4	<0.001

Values are expressed as median (interquartile range) or mean ± standard deviation.
⁺⁺⁺Statistical comparison between time 0 and recovery phase.
Δ: variation; HbA1c: glycated hemoglobin; HDL: high-density lipoprotein; LDL: low-density lipoprotein; HOMA-IR: homeostasis model assessment of insulin resistance; SBP: systolic blood pressure; DBP: diastolic blood pressure.