Research Article

Oral Glutamine Is Superior Than Oral Glucose to Promote Glycemia Recovery in Mice Submitted to Insulin-Induced Hypoglycemia

Figure 3

Glycemic response after oral administration of saline (Sal), glucose (Glu), glycerol (Gly), lactate (Lac), glutamine (Gln), or alanine (Ala) during insulin-induced hypoglycemia (IIH). IIH was induced in 14 hr fasted mice with an intraperitoneal injection of regular insulin (1.0 U·kg−1). Glycemia (mg·dL−1) was determined 0, 15, 30, 60, 120, 180, 240, and 300 min after insulin injection. The oral administration of Sal, Glu (100 mg·kg−1), Gly (100 mg·kg−1), Lac (100 mg·Kg−1), Gln (100 mg·kg−1), and Ala (100 mg·kg−1) was done 15 min after insulin injection. The bars express the mean ± standard deviation of 6–8 experiments. 15 min versus 60 min, 60 min versus 180 min, and 60 min versus 300 min.
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