About this Journal Submit a Manuscript Table of Contents
International Journal of Endocrinology
Volume 2013 (2013), Article ID 842598, 7 pages
http://dx.doi.org/10.1155/2013/842598
Clinical Study

The Relationship between Serum Osteocalcin Concentration and Glucose Metabolism in Patients with Type 2 Diabetes Mellitus

1Department of Endocrinology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310016, China
2Department of Endocrinology, Zhejiang Qingchun Hospital, Hangzhou 310016, China

Received 1 November 2012; Revised 9 January 2013; Accepted 12 February 2013

Academic Editor: Peng-Fei Shan

Copyright © 2013 Qingqing Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. A. Pearson, “Bone health and osteoporosis: the role of vitamin K and potential antagonism by anticoagulants,” Nutrition in Clinical Practice, vol. 22, no. 5, pp. 517–544, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. K. J. Motyl, L. R. McCabe, and A. V. Schwartz, “Bone and glucose metabolism: a two-way street,” Archives of Biochemistry and Biophysics, vol. 503, no. 1, pp. 2–10, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. N. K. Lee, H. Sowa, E. Hinoi et al., “Endocrine regulation of energy metabolism by the skeleton,” Cell, vol. 130, no. 3, pp. 456–469, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Yoshida, P. F. Jacques, J. B. Meigs et al., “Effect of vitamin K supplementation on insulin resistance in older men and women,” Diabetes Care, vol. 31, no. 11, pp. 2092–2096, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. M. K. Shea, C. M. Gundberg, J. B. Meigs et al., “γ-carboxylation of osteocalcin and insulin resistance in older men and women,” The American Journal of Clinical Nutrition, vol. 90, no. 5, pp. 1230–1235, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. J. J. Wen, L. M. Chen, C. Y. Shan et al., “The correlation between glycated hemoglobin A1c and islet β cell function in poorly controlled type 2 diabetic patients treated with oral antidiabetic drugs,” Chinese Journal of Diabetes, vol. 20, no. 2, pp. 129–132, 2012.
  7. S. Del Prato, A. M. Felton, N. Munro, R. Nesto, P. Zimmet, and B. Zinman, “Improving glucose management: ten steps to get more patients with type 2 diabetes to glycaemic goal,” International Journal of Clinical Practice, vol. 59, no. 11, pp. 1345–1355, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. J. M. Kindblom, C. Ohlsson, O. Ljunggren et al., “Plasma osteocalcin is inversely related to fat mass and plasma glucose in elderly Swedish men,” Journal of Bone and Mineral Research, vol. 24, no. 5, pp. 785–791, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. J. A. Im, B. P. Yu, J. Y. Jeon, and S. H. Kim, “Relationship between osteocalcin and glucose metabolism in postmenopausal women,” Clinica Chimica Acta, vol. 396, no. 1-2, pp. 66–69, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. B. B. Yeap, S. A. P. Chubb, L. Flicker et al., “Reduced serum total osteocalcin is associated with metabolic syndrome in older men via waist circumference, hyperglycemia, and triglyceride levels,” European Journal of Endocrinology, vol. 163, no. 2, pp. 265–272, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Zhou, X. Ma, H. Li et al., “Serum osteocalcin concentrations in relation to glucose and lipid metabolism in Chinese individuals,” European Journal of Endocrinology, vol. 161, no. 5, pp. 723–729, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. P. Du, G. Qin, and Z. Li, “Relationship between osteocalcin and type 2 diabetes mellitus,” Chinese Journal of Practical Meicine, vol. 38, no. 7, pp. 48–49, 2011.
  13. M. Ferron, E. Hinoi, G. Karsenty, and P. Ducy, “Osteocalcin differentially regulates β cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 13, pp. 5266–5270, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. I. Kanazawa, T. Yamaguchi, M. Yamauchi et al., “Serum undercarboxylated osteocalcin was inversely associated with plasma glucose level and fat mass in type 2 diabetes mellitus,” Osteoporosis International, vol. 22, no. 1, pp. 187–194, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. S. L. Booth, G. Dallal, M. K. Shea, C. Gundberg, J. W. Peterson, and B. Dawson-Hughes, “Effect of vitamin K supplementation on bone loss in elderly men and women,” Journal of Clinical Endocrinology and Metabolism, vol. 93, no. 4, pp. 1217–1223, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. C. M. Gundberg, S. D. Nieman, S. Abrams, and H. Rosen, “Vitamin K status and bone health: an analysis of methods for determination of undercarboxylated osteocalcin,” Journal of Clinical Endocrinology and Metabolism, vol. 83, no. 9, pp. 3258–3266, 1998. View at Publisher · View at Google Scholar · View at Scopus
  17. Y. C. Hwang, I. K. Jeong, K. J. Ahn, and H. Y. Chung, “The uncarboxylated form of osteocalcin is associated with improved glucose tolerance and enhanced β-cell function in middle-aged male subjects,” Diabetes/Metabolism Research and Reviews, vol. 25, no. 8, pp. 768–772, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Prats-Puig, M. Mas-Parareda, E. Riera-Pérez et al., “Carboxylation of osteocalcin affects its association with metabolic parameters in healthy children,” Diabetes Care, vol. 33, no. 3, pp. 661–663, 2010. View at Publisher · View at Google Scholar · View at Scopus