- About this Journal
- Abstracting and Indexing
- Aims and Scope
- Article Processing Charges
- Articles in Press
- Author Guidelines
- Bibliographic Information
- Citations to this Journal
- Contact Information
- Editorial Board
- Editorial Workflow
- Free eTOC Alerts
- Publication Ethics
- Reviewers Acknowledgment
- Submit a Manuscript
- Subscription Information
- Table of Contents
International Journal of Endocrinology
Volume 2013 (2013), Article ID 842598, 7 pages
The Relationship between Serum Osteocalcin Concentration and Glucose Metabolism in Patients with Type 2 Diabetes Mellitus
1Department of Endocrinology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310016, China
2Department of Endocrinology, Zhejiang Qingchun Hospital, Hangzhou 310016, China
Received 1 November 2012; Revised 9 January 2013; Accepted 12 February 2013
Academic Editor: Peng-Fei Shan
Copyright © 2013 Qingqing Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- D. A. Pearson, “Bone health and osteoporosis: the role of vitamin K and potential antagonism by anticoagulants,” Nutrition in Clinical Practice, vol. 22, no. 5, pp. 517–544, 2007.
- K. J. Motyl, L. R. McCabe, and A. V. Schwartz, “Bone and glucose metabolism: a two-way street,” Archives of Biochemistry and Biophysics, vol. 503, no. 1, pp. 2–10, 2010.
- N. K. Lee, H. Sowa, E. Hinoi et al., “Endocrine regulation of energy metabolism by the skeleton,” Cell, vol. 130, no. 3, pp. 456–469, 2007.
- M. Yoshida, P. F. Jacques, J. B. Meigs et al., “Effect of vitamin K supplementation on insulin resistance in older men and women,” Diabetes Care, vol. 31, no. 11, pp. 2092–2096, 2008.
- M. K. Shea, C. M. Gundberg, J. B. Meigs et al., “γ-carboxylation of osteocalcin and insulin resistance in older men and women,” The American Journal of Clinical Nutrition, vol. 90, no. 5, pp. 1230–1235, 2009.
- J. J. Wen, L. M. Chen, C. Y. Shan et al., “The correlation between glycated hemoglobin A1c and islet β cell function in poorly controlled type 2 diabetic patients treated with oral antidiabetic drugs,” Chinese Journal of Diabetes, vol. 20, no. 2, pp. 129–132, 2012.
- S. Del Prato, A. M. Felton, N. Munro, R. Nesto, P. Zimmet, and B. Zinman, “Improving glucose management: ten steps to get more patients with type 2 diabetes to glycaemic goal,” International Journal of Clinical Practice, vol. 59, no. 11, pp. 1345–1355, 2005.
- J. M. Kindblom, C. Ohlsson, O. Ljunggren et al., “Plasma osteocalcin is inversely related to fat mass and plasma glucose in elderly Swedish men,” Journal of Bone and Mineral Research, vol. 24, no. 5, pp. 785–791, 2009.
- J. A. Im, B. P. Yu, J. Y. Jeon, and S. H. Kim, “Relationship between osteocalcin and glucose metabolism in postmenopausal women,” Clinica Chimica Acta, vol. 396, no. 1-2, pp. 66–69, 2008.
- B. B. Yeap, S. A. P. Chubb, L. Flicker et al., “Reduced serum total osteocalcin is associated with metabolic syndrome in older men via waist circumference, hyperglycemia, and triglyceride levels,” European Journal of Endocrinology, vol. 163, no. 2, pp. 265–272, 2010.
- M. Zhou, X. Ma, H. Li et al., “Serum osteocalcin concentrations in relation to glucose and lipid metabolism in Chinese individuals,” European Journal of Endocrinology, vol. 161, no. 5, pp. 723–729, 2009.
- P. Du, G. Qin, and Z. Li, “Relationship between osteocalcin and type 2 diabetes mellitus,” Chinese Journal of Practical Meicine, vol. 38, no. 7, pp. 48–49, 2011.
- M. Ferron, E. Hinoi, G. Karsenty, and P. Ducy, “Osteocalcin differentially regulates β cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 13, pp. 5266–5270, 2008.
- I. Kanazawa, T. Yamaguchi, M. Yamauchi et al., “Serum undercarboxylated osteocalcin was inversely associated with plasma glucose level and fat mass in type 2 diabetes mellitus,” Osteoporosis International, vol. 22, no. 1, pp. 187–194, 2011.
- S. L. Booth, G. Dallal, M. K. Shea, C. Gundberg, J. W. Peterson, and B. Dawson-Hughes, “Effect of vitamin K supplementation on bone loss in elderly men and women,” Journal of Clinical Endocrinology and Metabolism, vol. 93, no. 4, pp. 1217–1223, 2008.
- C. M. Gundberg, S. D. Nieman, S. Abrams, and H. Rosen, “Vitamin K status and bone health: an analysis of methods for determination of undercarboxylated osteocalcin,” Journal of Clinical Endocrinology and Metabolism, vol. 83, no. 9, pp. 3258–3266, 1998.
- Y. C. Hwang, I. K. Jeong, K. J. Ahn, and H. Y. Chung, “The uncarboxylated form of osteocalcin is associated with improved glucose tolerance and enhanced β-cell function in middle-aged male subjects,” Diabetes/Metabolism Research and Reviews, vol. 25, no. 8, pp. 768–772, 2009.
- A. Prats-Puig, M. Mas-Parareda, E. Riera-Pérez et al., “Carboxylation of osteocalcin affects its association with metabolic parameters in healthy children,” Diabetes Care, vol. 33, no. 3, pp. 661–663, 2010.