Table 1: Main findings about FDG-PET or PET/CT in Hürthle cell thyroid carcinoma, anaplastic thyroid carcinoma, and poorly differentiated thyroid carcinoma.

TypeAuthorsYearDevicePatientsSensitivitySpecificityComments

HCTCPryma et al. [16]2006PET or PET/CT4495.8%95%FDG-PET has excellent diagnostic accuracy in HCTC, improving on CT and radioiodine scintigraphy. Intense FDG uptake is indicator of a poor prognosis. Patients with HCTC should undergo FDG-PET as part of their initial postoperative staging and periodically to screen for occult recurrence, particularly in patients with elevated serum thyroglobulin
Lowe et al. [17]2003PET1291.6%N.A.HCTC demonstrates intense FDG uptake. PET improves disease detection and disease management in HCTC relative to anatomic or radioiodine imaging. FDG-PET should be recommended for the evaluation and clinical management of HCTC
Plotkin et al. [18]2002PET17100%60%This study supports the efficiency of FDG-PET in the followup of HCTC

ATCGrabellus et al. [9]2012PET/CT4100%N.A.ATC shows intense FDG uptake. FDG-PET/CT is an important imaging modality for ATC
Poisson et al. [19]2010PET/CT20100%N.A.FDG-PET/CT appears to be the reference imaging modality for ATC at initial staging and seems promising in the early evaluation of treatment response and followup
Bogsrud et al. [20]2008PET16100%N.A.FDG-PET may improve disease detection and have an impact on the management of patients with ATC relative to other imaging modalities

PDTCGrabellus et al. [9]2012PET/CT2286.3%N.A.PDTC shows intermediate FDG uptake between DTC and ATC. FDG-PET/CT is an important imaging modality for PDTC

Legend: N.A.: not available; DTC: differentiated thyroid carcinoma; PDTC: poorly differentiated thyroid carcinoma; ATC: anaplastic thyroid carcinoma; HCTC: Hürthle cell thyroid carcinoma.