Intrahepatic Lipid Content and Insulin Resistance Are More Strongly Associated with Impaired NEFA Suppression after Oral Glucose Loading Than with Fasting NEFA Levels in Healthy Older Individuals

Table 2

Associations between standardised measures of insulin sensitivity (as exposures) and measures of NEFA metabolism (as outcomes).

	Fasting NEFA			NEFA suppression at 30 minutes			NEFA suppression at 60 minutes
	β	95% CI	P	β	95% CI	P	β	95% CI	P
Unadjusted
zLAR	−17.8	[−75.8, 40.3]	0.54	−7.9	[−13.0, −2.8]	0.003	−6.0	[−10.0, −2.1]	0.003
zOGIS	10.4	[-46.4, 67.2]	0.72	9.1	[4.2, 13.9]	<0.001	5.6	[1.6, 9.5]	0.006
zHOMA	15.6	[36.2, 67.4]	0.55	−3.6	[−8.4, 1.2]	0.14	−1.8	−5.6, 2.1	0.35
Adjusted^a
zLAR	−31.6	[−105.3, 42.1]	0.39	−11.9	[−18.7, −5.1]	0.001	−7.3	[−12.6, -2.0]	0.008
zOGIS	−25.0	[−88.3, 38.3]	0.43	11.0	[5.4, 16.7]	<0.001	4.4	[−0.2, 9.1]	0.062
zHOMA	49.4	[−4.5, 103.3]	0.07	−3.6	[−9.1, 1.9]	0.19	0.02	[−4.2, 4.2]	0.99

aAdjusted for age, gender, MR VAT, and alcohol consumption.
NEFA: nonesterified fatty acids.
zHOMA: standardised homeostasis model assessment.
zLAR: standardised leptin : adiponectin ratio.
zOGIS: standardised oral glucose insulin sensitivity.