Table 1: Relation between adipokines and bone metabolism.

AdipokinesOsteogenicOsteoclasticRelationship with BMD

AdiponectinPromotes the MSCs osteogenesis and osteoblast maturation [48]Inhibits the osteoclastogenesis and osteoclastic activity [810]Negative related with the BMD; a predictor of osteoporotic fractures in certain population [1012, 5963]

LeptinStimulate osteogensis both in vitro studies and subcutaneous injection animal model [13, 6469]Inhibits the osteoclastogenesis and osteoclastic activity [1417, 70, 71]No relationship was found after adjust for age, gender and hormone [11, 1836]

ResistinStimulates proliferation and weakly promotes the osteoblasts maturation [37]Strongly increases the number and activity of osteoclast [37]Negative related with certain population [10, 24]

VisfatinStimulates human osteoblast proliferation, maturation, and mineralization [38, 39]Inhibits the formation of osteoclast [40]No relationship was found [24, 33, 41, 42]

VaspinInhibits the apoptosis of osteoblast [43]No paper publishedNo paper published

ChemerinNegative effect by greatly promoting the adipogenesis of the MSCs [44]No paper publishedNo paper published

Omentin-1Inhibits the osteoblastic differentiation [45]No paper publishedNot clear, need more data [42, 72]