Table 2: Serum and urinary measurements (mean ± SD, or median values). Patient’s characteristics by estrogen use and menstrual history.

Laboratory testNormal range All patientsAmenorrheic
women1
Current
estrogen use
Eugonadal
women

Serum corrected calcium [2.25–2.60 mmol/L]642.35 ± 0 .092.34 ± 0.12.35 ± 0.12.36 ± 0.1
Serum phosphate [0.80–1.4 mmol/L]631.3 (0.3)1.3 (0.2)1.3 (0.2)1.5 (0.4)
Serum creatinine [35–88 µmol/L]6571.85 ± 11.3271.9 ± 12.974.1 ± 8.467.8 ± 8.6
Serum protein[61–79 g/L]4566.0 ± 6.465.9 ± 6.665.8 ± 6.466.4 ± 6.8
Serum albumin[35–48 g/L]6438.26 ± 4.5140.5 ± 4.5°37.3 ± 3.638.1 ± 4.7
Serum osteocalcin [8.8–29.7 μg/L]4420.49 ± 11.3019.2 ± 11.219.3 ± 9.028.4 ± 14.1
Serum total alkaline phosphatase [30–125 IU/L]6146 (18)48 (21) 41 (10)*51 (14)
Serum IGF-I [116–447 ng/mL]66118 (86)103 (81)129 (81)144 (133)
Serum IGFBP-3[3.3–6.7 µg/mL]344.63 ± 1.214.4 ± 1.34.9 ± 1.04.9 ± 1.2
Serum parathyroid hormone [1.1–6.8 pmol/L]583.1 (1.5)3.0 (1.4)3.0 (1.8)3.7 (1.3)
25-hydroxyvitamin D [25–120 nmol/L]5774 (43)69 (36)76 (66)73 (65)
Urinary calcium/creatinine [0.10–0.50 mmol/mmol]590.37 (0.44)0.6 (0.6)°0.3 (0.3)0.2 (0.3)
Urinary D-pyr/cr2[4.2–18.2 nmol/mmol]5217.7 (10.1)18.1 (7.0)13.4 (11.0)16.0 (10.1)
TRCaI/GFR3[2.4–2.9 mmol/L GFR]552.59 ± 0 .212.54 ± 0.22.64 ± 0.22.67 ± 0.2
TmPi/GFR4[0.8–1.4 mmol/L GFR]551.4 (0.3)1.4 (0.3)1.3 (0.3)1.5 (0.5)

Age-adjusted normal values were taken into account.
1At the time of evaluation, and including 3 patients taking oral contraceptives, but continuing to be amenorrheic.
2Deoxypyridinoline/creatinine.
3Renal tubular reabsorption of calcium index.
4Renal tubular reabsorption of phosphate.
versus current estrogen use and eugonadal women.
current estrogen versus eugonadal women.