Major Histocompatibility Class II Pathway Is Not Required for the Development of Nonalcoholic Fatty Liver Disease in Mice

Figure 3

Effect of high-fat diet on liver enzymes, lipids, and inflammatory markers in wild-type and MHCII^Δ/Δ mice. Open bars represent wild-type and closed bars MHCII^Δ/Δ mice (wild-type: 𝑛=25, MHCII^Δ/Δ: 𝑛=20). Data are presented as mean ± SEM. (a) Plasma ALT level at 16th week. (b) Plasma AST level. (c) Liver triglyceride content at 16th week. (d) Fasting active plasma PAI-1 concentration at 16th week. (e) Gene expression related to inflammation and fibrogenesis in the liver at 16th week.

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