Major Histocompatibility Class II Pathway Is Not Required for the Development of Nonalcoholic Fatty Liver Disease in Mice
Figure 6
Effect of 4-week CCl4 treatment on hepatic gene expression and fibrosis in wild-type and MHCIIΔ/Δ mice. Open bars represent oil-treated wild-type (WT-oil, ), closed bars CCl4-treated wild-type (WT-CCl4, ), gray bars oil-treated MHCIIΔ/Δ mice (MHCIIΔ/Δ-oil, ), semiclosed bars CCl4-treated MHCIIΔ/Δ mice (MHCIIΔ/Δ-CCl4, ). Data are presented as mean ± SEM. (a) MHC II gene expression. (b) Gene expression related to fibrosis formation. (c) Gene expression related to inflammation. (d) No difference in fibrosis (%) between groups treated by CCl4. The percentage was determined based on the sirius red staining (5 pictures/mice, WT-CCl4: , MHCIIΔ/Δ-CCl4: ). , ANOVA and Tukey Kramer HSD test. Different letters indicate the significant difference between groups.
