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International Journal of Endocrinology
Volume 2013 (2013), Article ID 976810, 7 pages
http://dx.doi.org/10.1155/2013/976810
Research Article

Analysis of Inflammatory Mediators in Type 2 Diabetes Patients

1Health & Social Development Sector, The Research Council of Oman, P.O. Box 1422, 130 Muscat, Oman
2Emergency Departments, Sultan Qaboos University Hospital (SQUH), P.O. Box 35, 123 Muscat, Oman
3Studies & Planning, Statistics Section, The Research Council, P.O. Box 1422, 130 Muscat, Oman
4Public Health, Armed Forces Medical Services Headquarters, Ministry of Defense, P.O. Box 928, 13 Muscat, Oman
5Department of Non-Communicable Diseases Surveillance and Control, Ministry of Health, P.O. Box 393, 100 Muscat, Oman

Received 5 March 2013; Accepted 10 April 2013

Academic Editor: Ilias Migdalis

Copyright © 2013 Ahmed Al-Shukaili et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The main aim of this study is to assess the inflammatory markers in type 2 diabetes mellitus (T2DM) by measuring some cytokines concentrations and lymphocytes subset and correlate them with other laboratory investigations. Fifty-seven patients with type-2 diabetes and 30 healthy volunteers were enrolled in this study. Data for the C-reactive protein (CRP), haemoglobin, HbA1c, and autoantibody levels were obtained from the patients files. The cytokine concentrations were measured in patient’s serum using commercially available ELISA assays. Lymphocytes subsets were measured by flow cytometric methods. The levels of IL-1 , IL-6, IL-15, and TNF- were found to be decreased in T2DM patients, whereas the levels of IL-10, IFN- , and caspase-1 were increased, compared to normal controls. T2DM patients with hypertension show significantly decreased levels of IL-1 and caspase-1 compared to patients without hypertension. No significant differences in lymphocytes subset between cases and normal control were observed. Significant correlations were found between HbA1c and IL-6; body mass index (BMI) was significantly correlated with CRP, TNF- , and phosphate; the weight (Wt) was associated with CRP and IFN- . In conclusion, an alteration in the function of the immune system was observed in T2DM patient.