The Changes in the Endothelial Function and Haemostatic and Inflammatory Parameters in Subclinical and Overt Hyperthyroidism
Table 2
Selected markers of inflammation and endothelial dysfunction in the patients with overt (OH) and subclinical hyperthyroidism (SH) and in the control group.
OH () median (C25–C75)
SH () median (C25–C75)
Control () median (C25–C75)
value
IL-6 (ng/mL)
1.8 (1.1–2.9)
1.7 (1.1–3..8)
1.2 (0.7–1.8)
,
IL-12 (pg/mL)
3.1 (1.7–5.7)
1.8 (0.65–4.6)
0.5 (0.5–1.4)
, ,
IL-18 (pg/mL)
276.3 (186.0–368.5)
212.8 (161.0–300.2)
232.8 (181.1–257.8)
,
CRP (ng/mL)
3.7 (3.1–5.4)
3.6 (2.7–4.7)
3.2 (2.7–4.3)
NS
Fibrinogen (mg/dL)
314.5 (253.5–374.0)
245.0 (172.0–303.0)
244.0 (185.0–325.0)
,
PAI-1 (ng/mL)
54.6 (32.9–84.5)
59.3 (28.0–88.4)
31.5 (18.2–47.0)
,
vWF (ng/mL)
129.3 (117.0–144.4)
111.8 (987–132.5)
94.2 (73.0–116.3)
,
E-selectin (ng/mL)
45.0 (34.0–68.0)
52.0 (36.0–70.0)
58.0 (40.0–68.0)
NS
sICAM-1 (ng/mL)
351.0 (294.0–409.0)
316.0 (262.0–378.0)
314.0 (278.0–404.0)
NS
sVCAM-1 (ng/mL)
1129.2 (943.0–1580.5)
1107.0 (835.0–1380.0)
792.0 (607.0–1010.0)
,
Data are shown as medians with interquartile ranges. Differences between groups were compared by the Kruskal-Wallis test.
*Differences between OH and control groups, **differences between SH and control groups, ***differences between OH and SH, NS: not significant.