Honokiol Protected against Heatstroke-Induced Oxidative Stress and Inflammation in Diabetic Rats

Table 4

The serum levels of blood urea nitrogen (BUN), creatinine (C), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphate (AP) for (NTDR + V) group, (HSDR + V) group, and (HSDR + H) group.

Treatment groups/time	BUN (mmol/L)	C (mmol/L)	ALT (U/L)	AST (U/L)	AP (U/L)
(1) NTDR + V:
0 min	8.4±0.7 (8)	28±2 (8)	36±3 (8)	112±9 (8)	308±22 (8)
60 min	8.6±0.6 (8)	26±3 (8)	34±4 (8)	115±7 (8)	314±24 (8)
(2) HSDR + V:
0 min	8.6±0.8 (8)	26±3 (8)	35±4 (8)	114±8 (8)	301±21 (8)
60 min	22±0.9^∗ (8)	72±4^∗ (8)	135±6^∗ (8)	556±7^∗ (8)	583±27^∗ (8)
(3) HSDR + H:
0 min	8.5±0.7 (8)	25±4 (8)	32±4 (8)	109±8 (8)	299±24 (8)
60 min	11±1.1^+ (8)	48±5^+ (8)	79±5^+ (8)	196±6^+ (8)	402±19^+ (8)

All heatstroke rats which had heat exposure (43°C) were withdrawn exactly at 60 minutes and then allowed to recover at room temperature (26°C). Data are mean ± SD, followed by number of animals in parentheses.
 ^∗𝑃<0.01, in comparison with Group 1.
 ⁺𝑃<0.05, in comparison with Group 2 (Dunn’s test followed by Kruskal-Wallis test). Vehicle solution (V) or honokiol (H) was adopted 60 min before the start of heat stress.