Negative Influence of a Long-Term High-Fat Diet on Murine Bone Architecture
Figure 6
Transmission electron microscopy. In comparison to controls (a)–(c) the HFD mice (d)–(f) showed less cell-to-cell (cc) and cell-to-matrix contacts ((a), (d)). More apoptotic formations (ap) were found in osteocytes (OT, (e)) and osteoblasts (Ob, (f)) of HFD mice that also contained less rough endoplasmatic reticulum (rER) in comparison to control animals (c). mb = mineralized bone; rb = ruffled border of a osteoclast. Scale bar: 5 μm in (a), (f), 2 μm in (b), (d)-(e), and 1 μm in (c).
