Taurine Alleviates the Progression of Diabetic Nephropathy in Type 2 Diabetic Rat Model
Figure 5
Effects of taurine on the expression of VEGF and nephrin in renal cortex. (a) Glomerular VEGF immunohistochemistry (arrows) in each group (×400). (b) Optical densities of VEGF in the glomeruli decreased significantly in the taurine-treated diabetic group compared to the diabetic control group. ((c), (d)) In the taurine-treated diabetic group, renal VEGF expression by western blot immunostaining decreased compared to that of the diabetic control group. ((e), (f)) The nephrin levels increased in taurine-treated group compared to diabetic control group. However the nephrin levels also increased in diabetic control group compared to normal control. But the VEGF and nephrin levels are not statistically significant. LETO, normal control group; OLETF, diabetic control group; OLETF + TA, taurine-treated diabetic group; VEGF, vascular endothelial growth factor. Data are expressed as mean ± SEM. * compared with LETO; † compared with OLETF.
