International Journal of Endocrinology

Clinical Study

Sexual Well-Being in Adult Male Patients with Congenital Adrenal Hyperplasia

Table 3

Biochemical and hormonal parameters in male patients with 21-OHD depending on AD/T ratio at study start (baseline).


	AD/T ratio <0.2	AD/T ratio >0.2

BMI (kg/m²)	25.4 ± 5.9	27.8 ± 4.8
BP systolic/diastolic (mmHg)	120/79 ± 14/7	119/79 ± 6/6
Potassium (mmol/L)	3.81 ± 0.36	3.68 ± 0.55
Sodium (mmol/L)	141.2 ± 0.9	140.0 ± 2.8
Cholesterol (mg/dL)	178 ± 40	154 ± 22
Triglycerides (mg/dL)	106 ± 68	100 ± 44
17-OHP (ng/mL)	2.7 ± 2.5	35.2 ± 16.1***
Androstenedione (ng/mL)	0.52 ± 0.27	3.28 ± 3.36*
DHEAS (ng/mL)	425 ± 239	944 ± 1228
Testosterone (ng/mL)	5.7 ± 2.6	4.0 ± 2.4
Free testosterone index	47.0 ± 12.5	33.1 ± 17.4
AD/T ratio	0.09 ± 0.03	0.94 ± 0.68***
Estradiol (pg/mL)	25.5 ± 8.3	28.2 ± 3.4
LH basal (U/L)	4.4 ± 2.4	3.6 ± 1.9
max LH	31.5 ± 10.1	18.5 ± 8.1*
FSH basal (U/L)	8.1 ± 7.9	4.5 ± 1.3
max FSH	7.1 ± 5.1	2.8 ± 1.9
No. of adrenal crisis during 2-year follow-up	2	1
% of patients with TART	18%	17%
daily GC equivalent dose/m² BSA (mg/m²)	20.5 ± 5.7	18.7 ± 6.2
% of patients receiving any treatment regimen with dexamethasone	55%	0%*
% SW	64%	67%
Daily fludrocortisone dose/m² BSA (mg/m²),	60.1 ± 15.4	53.5 ± 7.1

Data are means ± SD. BMI: body mass index; BP: blood pressure; BSA: body surface area. Normal ranges (SI units shown in brackets): sodium 134–145 mmol/L; potassium 3.4–5.2 mmol/L; cholesterol < 200 mg/dL (5.17 mmol/L); triglycerides < 180 mg/dL (2.06 mmol/L). Conversion factors: androstenedione (AD) X3.49 nmol/liter; testosterone (T) X3.47 nmol/liter; 17-hydroxy-progesterone (17OHP) X3.026 nmol/liter; estradiol X3.67 pmol/liter; and DHEAS X2.57 nmol/liter. max denotes the differences between peak and basal LH or FSH concentration. The dose of daily glucocorticoid was converted into milligrams of daily hydrocortisone equivalent (1 mg dexamethasone = 14 mg prednisolone = 70 mg hydrocortisone). Free testosterone index (fTI) was calculated by the ratio 347 * testosterone (ng/mL)/SHBG (nmol/L) [31]. Only in SW CAH patients. ; .