Clinical Study

Effects of Five-Year Treatment with Testosterone Undecanoate on Metabolic and Hormonal Parameters in Ageing Men with Metabolic Syndrome

Table 2

Effects of five-year testosterone undecanoate treatment on anthropometric and hormonal parameters in 40 hypogonadal men with metabolic syndrome. variations were evaluated yearly in the testosterone treatment (TRT) versus controls (CTRL).

Baseline 12 months24 months36 months48 months60 months
CTRLTRT CTRLTRT CTRLTRT CTRLTRT CTRLTRT CTRLTRT

Tot-Chol./
HDL-Chol.
ns 0.001 0.0001 0.0001 0.0001 0.0001
Trigl. (mg/gL) ns 0.001 0.0001 0.0001 0.0001 0.0001
Heart rate (bpm) ns 0.001 0.001 0.0001 0.001 0.001
BMI (Kg/m2) ns ns ns ns ns ns
HOMA-I ns 0.0001 0.0001 0.0001 0.0001 0.0001
VIT D (ng/mL) ns 0.01 0.01 0.01 0.01 0.01
Total T (nmol/L) ns 0.0001 0.0001 0.0001 0.0001 0.0001
SHBG (nmol/L) ns ns ns ns ns ns
Estradiol (pg/mL) ns ns ns ns ns ns
TSH (mUI/mL) ns 0.01 0.01 0.01 0.01
GH (ng/mL) ns 0.0001 0.0001 0.0001 0.0001 0.0001
IGF1 (ng/mL) ns 0.01 0.01 0.01 0.01 0.01
Tot. PSA (ng/mL) ns 0.01 0.01 0.01 0.01
HCT (%) ns 0.001 0.001 0.001 0.001
Lumbar -score (SD) ns 0.005 0.0001 0.0001 0.0001
Neck -score (SD) ns 0.005 0.0001 0.0001 0.0001