Vitamin D Binding Protein Affects the Correlation of 25(OH)D and Frailty in the Older Men
Table 2
Selected demographic and study variables of the study sample across frailty categories.
Characteristics
Nonfrail ()
Prefrail ()
Frail ()
Age (y), mean (SD)
72.7 (4.1)
74.6 (5.2)
81.9 (4.4)
<0.05
BMI (kg/m2), mean (SD)
26.5 (3.6)
24.3 (5.2)
27.8 (6.1)
0.68
%BMI†
0.27
<20.0
4.6
10.3
18.1
20.0–<25.0
40.2
25.8
26.0
25.0–<28.0
33.9
29.1
25.6
≥28.0
21.3
34.8
30.3
Education (y), mean (SD)
7.8 (2.1)
5.8 (1.6)
4.1 (1.7)
<0.05
Smoking status (% current or previous smokers)
41.2
47.1
45.8
0.62
25(OH)D (nmol/L), mean (SD)
46.1 (11.2)
42.9 (8.3)
35.8 (10.1)
<0.05
DBP (nmol/L), mean (SD)
4576 (1676)
4876 (1319)
5323 (1213)
<0.05
Free 25(OH)D (pmol/L), mean (SD)
26.3 (7.2)
23.4 (5.2)
20.1 (4.3)
0.26
Albumin (g/L), mean (SD)
38.1 (2.1)
37.3 (2.3)
35.7 (2.6)
0.19
Serum calcium (mmol/L), mean (SD)
2.2 (0.2)
2.1 (0.3)
2.0 (0.3)
0.58
Parathyroid hormone (ng/L), mean (SD)
28.9 (7.8)
30.1 (11.6)
32.3 (9.1)
0.62
Notes: BMI: body mass index; 25(OH)D: 25-hydroxyvitamin D; DBP: vitamin D binding protein. values were determined using Jonckheere-Terpstra trend test. BMI was considered a categorical variable as defined and was adjusted in all the regression models.
