Mitochondrial DNA Copy Number in Peripheral Blood Is Independently Associated with Visceral Fat Accumulation in Healthy Young Adults

Table 3

Multiple regression analyses for mtDNA copy number^#.  

(a) Stepwise model

	β coefficient	SE	𝑃-value
Visceral fat area	−0.33	0.00	<0.01
Hs-CRP (mg/L)	−0.32	0.05	<0.01
Smoking^# (%)	−0.21	0.18	0.01
HDL-cholesterol (mg/dL)	0.21	0.39	0.04

𝑟²=0.35. Variables included in the stepwise model for mtDNA were age, sex, BMI, alcohol consumption, smoking, systolic BP, total cholesterol, HDL-cholesterol, fasting glucose, HOMA-IR and visceral fat area.
To avoid multi-collinearlity, diastolic BP, triglycerides and subcutaneous fat area were not included in the stepwise model.
#Values analyzed after log-transformation to correct for skewed distribution.

(b) Non-stepwise model

Variables	β coefficient	SE	𝑃-value
Age (years)	−0.05	0.02	0.30
Male (%)	0.03	0.20	0.89
BMI (kg/m^2)	−0.12	0.03	0.43
Smoking (%)	−0.42	0.20	0.03
Systolic BP (mm Hg)	0.00	0.01	0.69
Visceral fat area (cm^2)	−0.32	0.00	0.03
HDL-cholesterol (mg/dL)	0.21	0.42	0.07
Fasting glucose (mg/dL)	−0.04	0.00	0.66
HOMA-IR	−0.04	0.16	0.41
hs-CRP (mg/L)	−0.19	0.06	0.02

𝑟²=0.58. Variables included in the non-stepwise model for mtDNA were age, sex, BMI, smoking, systolic BP, HDL-cholesterol, fasting glucose, HOMA-IR and hs-CRP.