MicroRNAs in Diabetic Kidney Disease

Table 2

Summary of microRNAs in diabetic kidney disease (downregulation).

microRNA	In vitro (cell type)	In vivo (animal mode)	Target	References
miR-192	PTE human (HK-2 cells)	Patients with established DN	Zeb2	[60, 61]
miR-215	Primary MCs and PTCs (rat)	STZ induced DN in APOE knockout mice; (10 weeks of age)	Zeb2	[61]
miR-21	Primary MCs (mouse)	db/db mice; (8 weeks of age)	PTEN	[67]
miR-200a	TEC (rat)	STZ induced DN in apolipoprotein E knockout mice	TGF-β2	[88]
miR-29a	PTE human (HK-2 cells)		Col IVA1 and Col IVA2	[77]
miR-25	MCs (rat)	STZ induced DN rat	Nox4	[95]
miR-451	Primary MCs (mouse)	Early DN (db/db mice)	Ywhaz	[96]
miR-93	Renal microvascular; Endothelial cell; Mouse podocytes	db/db mice	VEGF-A	[94]

PTE: proximal tubule epithelial cells; TEC: tubular epithelial cells; MC: mesangial cells; STZ: streptozotocin; DN: diabetic nephropathy.