The Architecture of Risk for Type 2 Diabetes: Understanding Asia in the Context of Global Findings

Table 3

Population-specific odds ratios and risk allele frequencies for SNPs associated with T2D in multiple populations.

Number

SNPs

Ref allele

Disc Pop

RAF

OR (95% CI)

Ref allele

1st Rep Pop

RAF

OR (95% CI)

Ref allele

2nd Rep Pop

RAF

OR (95% CI)

1

rs1470579

C

EUR [116]

0.3

1.14 (1.09–1.19)

C

EA [177]

0.24

1.33 (1.20–1.48)

C

SA [152]

0.5

1.06 (1.04–1.08)

2

rs4402960

T

EUR [98]

0.3

1.14 (1.11–1.18)

T

EA [144]

0.22

1.14 (1.08–1.21)

3

rs7754840

C

EUR [103]

0.34

1.12 (1.08–1.16)

C

EA [146]

0.4

1.35 (1.23–1.48)

4

rs13266634

C

EUR [74]

0.76

1.12 (1.07–1.16)

C

EA [144]

0.53

1.22 (1.15–1.28)

5

rs2383208

A

EA [144]

0.59

1.34 (1.27–1.41)

A

SA [151]

0.91

1.23 (1.13–1.34)

6

rs1111875

C

EUR [98]

0.58

1.13 (1.09–1.17)

C

EA [144]

0.34

1.21 (1.15–1.28)

7

rs5015480

C

EUR [74]

0.58

1.13 (1.07–1.19)

C

EA [120]

0.21

1.17 (1.11–1.24)

8

rs7903146

T

EUR [99]

0.28

1.65 (1.28–2.02)

T

EA [144]

0.03

1.54 (1.36–1.74)

T

SA [178]

0.28

1.33 (1.19–1.49)

9

rs2237892

C

EA [113]

0.67

1.40 (1.34–1.47)

C

EA [113]

0.93

1.29 (1.11–1.50)

C

HIS [149]

0.79

1.09 (1.06–1.12)

10

rs7178572

G

SA [92]

0.44

1.09 (1.06–1.12)

G

EUR [171]

0.68

1.11 (1.07–1.15)

11

rs8050136

A

EUR [98]

0.46

1.17 (1.12–1.22)

A

SA [151]

0.25

1.16 (1.09–1.24)

12

rs4430796

G

EUR [116]

0.51

1.14 (1.08–1.20)

G

EA [146]

0.25

1.19 (1.13–1.25)

13

rs5945326

A

EUR [116]

0.78

1.27 (1.18–1.37)

A

EA [146]

0.66

1.18 (1.13–1.23)

14

rs4712523

G

EA [144]

0.41

1.27 (1.21–1.33)

G

EUR [115]

0.34

1.20 (1.14–1.26)

Population. EUR: European; SA: South Asian; EA: East Asian; HIS: Hispanic.