Effect of GAS6 and AXL Gene Polymorphisms on Adiposity, Systemic Inflammation, and Insulin Resistance in Adolescents
Table 2
Anthropometric and biochemical data with different GAS6 rs8191974 genotypes among boys and girls.
Boys
Girls
GG
GA
AA
GG
GA
AA
(n = 213)
(n = 132)
(n = 13)
(n = 242)
(n = 109)
(n = 18)
BMI (kg/m2)
22.5 ± 4.2b
22.0 ± 3.6b
20.7 ± 3.3b
21.2 ± 3.3
21.3 ± 3.4
20.3 ± 2.3
WC (cm)
80.6 ± 11.0b
79.3 ± 9.5b
76.7 ± 9.4b
75.8 ± 8.1
75.2 ± 8.2
74.6 ± 8.3
hsCRP (mg/L)
0.8 ± 1.2a,b
1.1 ± 1.6a,b
0.4 ± 0.2a,b
0.6 ± 1.0
0.5 ± 0.5
0.9 ± 1.3
TNF-α (pg/mL)
26.7 ± 8.2
25.5 ± 10.1
23.8 ± 4.6
24.5 ± 9.3
22.9 ± 6.5
27.9 ± 4.3
IL-6 (pg/mL)
3.4 ± 2.8
3.3 ± 3.2
2.5 ± 1.3
3.2 ± 2.8
3.1 ± 3.0
2.9 ± 0.7
Glucose (mg/dL)
94.0 ± 6.3
93.4 ± 6.4
95.3 ± 3.6
91.8 ± 6.7
90.6 ± 6.3
92.1 ± 5.7
Insulin (μU/mL)
14.9 ± 8.7
15.3 ± 9.0
15.0 ± 8.2
15.0 ± 8.1
13.9 ± 6.6
11.7 ± 4.2
HOMA-IR
3.5 ± 2.2
3.6 ± 2.2
3.5 ± 2.0
3.4 ± 2.0
3.1 ± 1.5
2.7 ± 1.1
Gas6 (ng/mL)
13.1 ± 3.7
13.2 ± 3.7
13.0 ± 3.1
11.8 ± 3.1
12.1 ± 3.0
1.7 ± 2.2
Data are expressed as mean ± SD. BMI: body mass index; WC: waist circumference; HOMA-IR: homeostasis model assessment of insulin resistance; hsCRP: high-sensitivity C-reactive protein; TNF-α: tumor necrosis factor-α; IL-6: interleukin-6.
aGG versus GA versus AA, P < 0.05; bGG versus (GA + AA), P < 0.05. All comparisons were analyzed using a general linear model after adjusting for age, Tanner stages, smoking status, drinking status, and physical activity.