Effect of GAS6 and AXL Gene Polymorphisms on Adiposity, Systemic Inflammation, and Insulin Resistance in Adolescents
Table 4
Anthropometric and biochemical data with different AXL rs2304232 genotypes among boys and girls.
Boys
Girls
AA
AG
GG
AA
AG
GG
(n = 180)
(n = 143)
(n = 35)
(n = 165)
(n = 161)
(n = 43)
BMI (kg/m2)
22.3 ± 3.7
22.2 ± 3.9
22.4 ± 5.4
21.4 ± 3.5
21.0 ± 3.3
21.2 ± 2.5
WC (cm)
79.8 ± 10.1
80.3 ± 10.0
79.5 ± 13.8
75.7 ± 8.6
75.5 ± 7.9
75.0 ± 7.3
hsCRP (mg/L)
0.9 ± 1.5
0.8 ± 1.0
0.8 ± 1.5
0.5 ± 0.8
0.5 ± 0.8
0.8 ± 1.4
TNF-α (pg/mL)
26.9 ± 6.0
25.2 ± 7.0
24.7 ± 7.7
24.7 ± 7.5
25.4 ± 8.4
28.1± 9.5
IL-6 (pg/mL)
3.1 ± 3.0a
3.2 ± 3.1a
4.8 ± 4.0a
3.2 ± 3.1
3.0 ± 1.8
3.7 ± 3.5
Glucose (mg/dL)
93.7 ± 5.8
94.0 ± 6.2
93.4 ± 8.4
91.3 ± 6.5
91.5 ± 6.7
92.0 ± 6.0
Insulin (μU/mL)
15.4 ± 9.3a
14.5 ± 8.2a
15.9 ± 8.6a
15.1 ± 7.5
14.0 ± 7.9
14.1 ± 6.1
HOMA-IR
3.6 ± 2.3a
3.4 ± 2.0a
3.7 ± 2.3a
3.4 ± 1.8
3.2 ± 1.9
3.2 ± 1.4
Data are expressed as mean ± SD. BMI: body mass index; WC: waist circumference; HOMA-IR: homeostasis model assessment of insulin resistance; hsCRP: high-sensitivity C-reactive protein; TNF-α: tumor necrosis factor-α; IL-6: interleukin-6.
a(AA + AG) versus GG, P < 0.05. All comparisons were analyzed using a general linear model after adjusting for age, Tanner stages, smoking status, drinking status, and physical activity.