Review Article

Genetic Susceptibility to Type 2 Diabetes and Obesity: Follow-Up of Findings from Genome-Wide Association Studies

Table 1

Type 2 diabetes loci established to date.

Gene symbolFull gene nameReferences

ADAMTS9 Thyroid adenoma associated (THADA), ADAM metallopeptidase with thrombospondin type 1 motif, 9[25]
ADCY5 Adenylate cyclase 5 (ADCY5)[14, 45]
ADRA2A Alpha-2a-adrenergic receptor[14]
AP3S2 Adaptor-related protein complex 3, sigma 2 subunit[35]
BCL11A B-cell cll/lymphoma 11A[22]
C2CD4B C2 calcium-dependent domain-containing protein[14]
CCNL1 Cyclin L1[14, 45]
CDC123-CAMK1D Cell division cycle 123 homolog/calcium/calmodulin-dependent protein kinase ID[25]
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1[1719, 23, 26]
CDKN2A/B Cyclin-dependent kinase inhibitor 2A/B[1719, 23, 26]
CENTD2 Centaurin, delta-2[22]
CHCHD9 Coiled-coil-helix-coiled-coil-helix domain 9[22]
CMIP c-Maf inducing protein[34]
CRY2 Cryptochrome 2[14]
DUSP9 Dual-specificity phosphatase 9[22]
FADS1 Fatty acid desaturase 1[14]
FITM2 Fat storage-inducing transmembrane protein 2[34]
GCC1 GRIP and coiled-coil domain containing 1[34]
GCK Glucokinase[14]
GCKR Glucokinase regulatory protein[14]
GLIS3 Glis family zinc finger protein 3 [14, 34]
GRB14 Growth factor receptor-bound protein 14[35]
HHEX Homeobox hematopoietically expressed[1719, 23, 26]
HMG20A High mobility group 20A[35]
HMGA2 High mobility group at-hook 2[22]
HNF1A Hepatocyte nuclear factor-1-alpha[22]
HNF1B HNF1 homeobox B[15]
HNF4A Hepatocyte nuclear factor-4-alpha[34, 35]
IGF1 Insulin-like growth factor 1[14]
IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2[1719, 23, 26]
IRS1 Insulin receptor substrate 1 [16]
JAZF1 Juxtaposed with another zinc finger gene 1[25]
KCNK16 Potassium channel, subfamily K, member 16[34]
KCNQ1 Potassium voltage gated channel, KQT-like subfamily, member 1[21, 22, 24]
KLF14 Kruppel-like factor 14[22]
MADD Map kinase-activating death domain[14]
MAEA Macrophage erythroblast attacher[34]
MTNR1B Melatonin receptor 1B gene[2729]
NOTCH2 neurogenic locus notch homolog protein 2[25]
PAX4 paired box 4[34]
PEPD peptidase D[34]
PPARG peroxisomal proliferator-activated receptor-g [11]
PRC1 protein regulating cytokinesis 1[22]
PROX1 prospero-related homeobox 1[14]
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6[34]
R3HDML R3H domain containing-like[34]
SLC16A11 solute carrier family 16, member 11[36]
SLC16A13 solute carrier family 16, member 13[36]
SLC2A2 solute carrier family 2, member 2[14]
SLC30A8 solute carrier family 30, member 8[1719, 23, 26]
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltransferase 1[35]
TCF7L2 transcription factor 7-like 2[31]
TMEM195 diacylglycerol kinase (DGKB)-transmembrane protein 195[14]
TP53INP1 Tumor protein p53-inducible nuclear protein 1[22]
TSPAN8-LGR5 tetraspanin 8/leucine-rich repeat containing G protein-coupled receptor 5[25]
VPS26A Vacuolar protein sorting 26 homolog A[35]
WWOX WW domain containing oxidoreductase[34]
ZBED3 zinc finger BED domain-containing protein 3[22]
ZFAND3 zinc finger, AN1-type domain 3[34]
ZFAND6 zinc finger, AN1-type, domain-containing protein 6[22]
Intragenic[1719, 23, 26]

Gene symbol, gene name, and references are provided for each locus.