Update on Anaplastic Thyroid Carcinoma: Morphological, Molecular, and Genetic Features of the Most Aggressive Thyroid Cancer
Figure 4
Neoplastic giant cells are characterized by deep pleomorphism, with bizarre multiple hyperchromatic nuclei (a). They differ from reactive osteoclast-like giant cells (b) that show bland cytological features and are typically immunoreactive for CD68-KP1 (inset).