Bone and Mineral Metabolism in Patients with Primary Aldosteronism

Table 3

Renin-angiotensin-aldosterone system parameters in all subjects enrolled.

Patient	PAC (ng/dL)	PRA (ng/mL/h)	PA/PRA ratio; (ng/mL : ng/mL/h)	PAC postinfusion test; (ng/dL)	AUR (𝜇g/24 h)
PA (n.73)	37±25.1^∗	0.9±0.7^∗	41.1±11.5^∗	115.9±78.7^∗	31.6±18.1^∗
EH (n.73)	22.5±13	1.4±1.6	16.7±7.3	24.5±8.7	16.3±4.5
HS (n.40)	9.2±1.7	1.1±0.4	8.4±2.8	—	18.3±5.3
𝑃	<0.001 versus EH-HS	<0.001 versus EH	<0.001 versus EH-HS	<0.001 versus EH	<0.001 versus EH-HS
APA (n.35)	39.8±25.6	0.7±0.6	56.9±15.2	148.1±95.7	34.3±22.8
IHA (n.38)	34.4±24.6	1.1±0.8	31.3±5.6	85.1±40.5	29.4±12.8
𝑃	ns	ns	ns	<0.001	ns

PA: primary aldosteronism; EH: essential arterial hypertension, HS: healthy subjects; APA: aldosterone-producing adrenal adenoma; IHA: idiopathic bilateral hyperplasia; PAC: plasma aldosterone concentration; PRA: plasma renin activity; AUR: 24-hour aldosterone urinary excretion.
^∗𝑃 value.