Bixin and Norbixin Have Opposite Effects on Glycemia, Lipidemia, and Oxidative Stress in Streptozotocin-Induced Diabetic Rats

Table 1

Effect of bixin and norbixin treatment on oxidative stress parameters in the blood of streptozotocin-induced diabetic rats.

Groups	GPx; (nmol NADPH/min/g Hb)	GR; (nmol NADPH/min/mg Hb)	TrxR; (nmol DTNB reduced/min/mg Hb)
Nondiabetic control	26.3±5.9	20.6±1.2	155.5±8.2
Diabetic vehicle	25.0±1.6	32.0±0.7	138.0±16.5
Diabetic + insulin	49.6±9.2^∗,#	18.2±2.9	172.7±21.3
Diabetic + metformin	29.8±8.3	23.9±11.1	142.1±11.4
Diabetic + bixin (10 mg/kg)	11.4±3.7	19.2±3.9	149.8±6.5
Diabetic + bixin (100 mg/kg)	19.7±6.5	61.8±10.9^∗,#	264.3±27.0^∗,#
Diabetic + norbixin (10 mg/kg)	26.0±9.5	18.0±1.2	96.3±11.2^∗,#
Diabetic + norbixin (100 mg/kg)	62.2±3.2^∗,#	17.2±2.3	150.9±12.7

Data are expressed as means ± SEM (𝑛=6  per group, except for the metformin and insulin groups that had 5 animals). ANOVA followed by Duncan’s test: *𝑃<0.05 versus nondiabetic control; ^#𝑃<0.05 versus diabetic vehicle.