Retrospective Analysis of Cushing’s Disease with or without Hyperprolactinemia

Table 2

Gender, tumor invasiveness, and the presence of pituitary apoplexy in the two groups of patients.

Variable	CD ( = 48)	PRL + CD ( = 36)	P
Gender
Male	15 (31.3%)	10 (27.8%)	0.461
Female	33 (68.8%)	26 (72.2%)
Invasion
+	11 (22.9%)	12 (33.3%)	0.289
−	37 (77.1%)	24 (66.7%)
Apoplexy
+	9 (18.8%)	6 (16.7%)	0.805
−	39 (81.3%)	30 (83.3%)
Classification Knosp
0	25 (52.1)	7 (19.4)	0.005
1	7 (14.6)	9 (25.0)
2	6 (12.5)	7 (19.4)
3	8 (16.7)	8 (22.2)
4	2 (4.2)	5 (13.9)

Data are expressed as (%). “+” and “−” indicate the presence and absence, respectively, of the characteristic in the group. P values were determined using a chi-square test or a Mann-Whitney tests. P < 0.05 was considered statistically significant.