International Journal of Endocrinology

Research Article

High Prevalence of Infertility among Women with Graves’ Disease and Hashimoto’s Thyroiditis

Table 1

Characteristics of the women with GD and HT who reported or did not report a period of infertility.


Characteristics	Infertility	No infertility	value

Graves’ disease	101 (52.3)	92 (47.7)
Age^a	44.3 (9.4)	42.2 (9.3)	NS^b
Age at menarche (years)^a	12.8 (1.8)	12.6 (1.6)	NS^b
Age at sexual debut (years)^a	17.6 (3.8)	17.5 (3.7)	NS^b
Age at diagnosis (years)^a	36.5 (9.8)	35.8 (9.1)	NS^b
Time of the disease (years)^a	7.8 (5.9)	6.3 (4.6)	NS^b
Exophthalmos	57 (56.4)	60 (65.2)	NS^c
Goiter volume (cm³)^a	26.4 (22.2)	26.2 (18.9)	NS^a
Thyroid nodule	28 (31.4)	25 (29.7)	NS^c
Anti-TPO	87 (87.9)	72 (84.7)	NS^c
Anti-Tg	61 (61.6)	52 (58.4)	NS^c
Other autoimmune diseases	11 (10.9)	11 (11.9)	NS^c
Family history of thyroid disease
Graves’ disease	14 (13.8)	14 (15.5)	NS^c
Hashimoto’s thyroiditis	13 (12.8)	7 (7.8)	NS^c
Family history of other autoimmune diseases	47 (46.5)	38 (42.2)	NS^c
Hashimoto’s thyroiditis	31 (47.0)	35 (53.0)
Age (years)^a	44.7 (10.4)	46.2 (10.8)	NS^b
Age at menarche (years)^a	12.4 (2.0)	12.4 (1.6)	NS^b
Age at sexual debut (years)^a	18.5 (3.8)	17.4 (3.1)	NS^b
Age at diagnosis (years)^a	39.2 (10.6)	37.1 (11.4)	NS^b
Time of the disease (years)^a	5.5 (4.2)	9.1 (5.6)	0.004^b
Goiter	10 (33.3)	13 (39.4)	NS^c
Goiter volume (cm³)^a	17.8 (22.3)	16.3 (11.8)	NS^b
Thyroid nodule	15 (50.0)	10 (30.3)	NS^c
Anti-TPO	27 (90.0)	33 (94.3)	NS^d
Anti-Tg	27 (87.1)	29 (82.8)	NS^d
Other autoimmune diseases	4 (12.9)	3 (8.6)	NS^d
Family history of thyroid disease
Graves’ disease	2 (6.7)	5 (14.3)	NS^d
Hashimoto’s thyroiditis	11 (36.7)	10 (28.6)	NS^c
Family history of other autoimmune diseases	18 (60.0)	18 (51.4)	NS^c

“Infertility” and “No infertility” groups refer, respectively, to the group of women who reported a period of infertility and the group of women who did not.
NS: not significant; values consist of means ± standard deviation of the mean; Mann-Whitney test; chi-square test; Fisher’s exact test; anti-TPO: antithyroid peroxidase antibodies; anti-Tg: antithyroglobulin antibodies.