High Prevalence of Infertility among Women with Graves’ Disease and Hashimoto’s Thyroiditis

Table 4

Factors associated with infertility in women with GD and HT, in the whole sample and the subgroups of age ≤35 years and >35 years, following multivariate logistic regression analysis.

Variable		OR (95% CI)	𝑃 value
Hashimoto’s thyroiditis
Time since diagnosis (years)	Continuous variable	0.84 (0.75–0.95)	0.007
Time since diagnosis	<6 years	6.17 (2.07–18.46)	0.001
	≥6 years	1.00
Time since diagnosis (years)∗	Continuous variable	0.83 (0.74–0.94)	0.004
Time since diagnosis∗	<6 years	6.18 (2.03–18.75)	0.001
	≥6 years	1.00
Age#	Continuous variable	0.77 (0.62–0.96)	0.025
Time since diagnosis&	<6 years	5.60 (1.36–23.06)	0.017
	≥6 years	1.00
Graves disease
Age∗	Continuous variable	1.05 (1.01–1.09)	0.010
Time since diagnosis (years)#	Continuous variable	1.08 (1.01–1.17)	0.047

OR: odds ratio; 95% CI: 95% confidence interval. ∗Adjusted for the association between number of pregnancies prior the diagnosis. Stepwise variable selection criteria. #Woman’s age ≤35 years subgroup (𝑛=27 for HT group; 𝑛=84 for GD group). &Woman’s age >35 years subgroup (𝑛=39 for HT group; 𝑛=109 for GD group). Variables studied: age, number of pregnancies and deliveries, total number of living children, total number of premature infants, total number of pregnancy losses, pregnancies prior to and following diagnosis, pregnancy losses prior to and following diagnosis, complications in pregnancy prior to and following diagnosis, age at diagnosis, time since diagnosis, anti-TPO antibodies, anti-Tg antibodies, goiter, volume of goiter, thyroid nodule, history of POI, history of other autoimmune diseases, and family history of thyroid disease.