Consequence of Menin Deficiency in Mouse Adipocytes Derived by In Vitro Differentiation
Table 1
Differentially regulated genes in Men1-KO versus WT adipocytes derived from mESCs.
Affymetrix probe set ID
Ref seq. transcript ID
Gene symbol
Gene title
Microarray fold change
QPCR fold change
1451634_at
NR_002853
Airn
Antisense Igf2r RNA
1457030_at
NR_028265
Mirg
miRNA containing gene
1438588_at
NM_009538
Plagl1
Pleiomorphic adenoma gene-like 1
1427580_a_at
NR_028261
Rian
RNA imprinted and accumulated in nucleus
1436713_s_at
NR_003633
Meg3
Maternally expressed gene 3
1417836_at
NM_024198
Gpx7
Glutathione peroxidase 7
1421461_at
NM_001122949
Mpl
Myeloproliferative leukemia virus oncogene
1418061_at
NM_013589
Ltbp2
Latent transforming growth factor beta binding protein 2
1428896_at
NM_026840
Pdgfrl
Platelet-derived growth factor receptor-like
1419411_at
NM_009312
Tac2
Tachykinin 2
1423506_a_at
NM_010923
Nnat
Neuronatin
1460412_at
NM_024237
Fbln7
Fibulin 7
1448788_at
NM_010818
Cd200
CD200 antigen
1421074_at
NM_007825
Cyp7b1
Cytochrome P450, family 7, subfamily b, and polypeptide 1
1419197_x_at
NM_032541
Hamp
Hepcidin antimicrobial peptide
1417979_at
NM_022322
Tnmd
Tenomodulin
1425040_at
NM_028593
Cybrd1
Cytochrome b reductase 1
1419292_at
NM_001042615
Htra3
HtrA serine peptidase 3
1435476_a_at
NM_001077189
Fcgr2b
Fc receptor, IgG, low affinity IIb
1416347_at
NM_001168488
Men1
Multiple endocrine neoplasia 1
1450285_at
NM_011667
Ube1y1
Ubiquitin-activating enzyme E1, Chr Y 1
1435064_a_at
NM_020626
Tmem27
Transmembrane protein 27
1448783_at
NM_021291
Slc7a9
Solute carrier family 7 (cationic amino acid transporter, y+ system), member 9
1456601_x_at
NM_007503
Fxyd2
FXYD domain-containing ion transport regulator 2
1424279_at
NM_001111048
Fga
Fibrinogen alpha chain
1418916_a_at
NM_029269
Spp2
Secreted phosphoprotein 2
1449907_at
NM_001163028
Bcmo1
Beta-carotene 15,15′-monooxygenase
1422289_a_at
NM_029636
Ctsq
Cathepsin Q
1418766_s_at
NM_001161355
Timd2
T-cell immunoglobulin and mucin domain-containing 2
1443824_s_at
NM_053070
Car7
Carbonic anhydrase 7
1417761_at
NM_007468
Apoa4
Apolipoprotein A-IV
1418724_at
NM_007686
Cfi
Complement component factor i
1440218_at
NM_001033364
Cdhr2
Cadherin-related family member 2
1452165_at
NM_025532
Prl2b1
Prolactin family 2, subfamily b, member 1
1451513_x_at
NM_009243
Serpina1a
Serine (or cysteine) peptidase inhibitor, clade A, member 1A
1418282_x_at
NM_009244
Serpina1b
Serine (or cysteine) peptidase inhibitor, clade A, member 1B
1424673_at
NM_053165
Clec2h
C-type lectin domain family 2, member h
1429826_at
NM_029355
Prl7b1
Prolactin family 7, subfamily b, member 1
1448572_at
NM_011165
Prl4a1
Prolactin family 4, subfamily a, member 1
1436717_x_at
NM_008221.4
Hbb-y
Hemoglobin Y, beta-like embryonic chain
Validation of top 20 downregulated or upregulated genes () identified in the gene expression microarray analysis. QPCR fold change was normalized to Gapdh. Bold, genes regulated by differential DNA methylation. Italic, genes from the prolactin gene family.