The Chromosome 9p21 CVD- and T2D-Associated Regions in a Norwegian Population (The HUNT2 Survey)
Table 2
Single point and two-point haplotype association results for T2D.
SNP
Minor allele
Single point
Two-point
Haplotype
OR (95% CI)
SNPs
Omnibus
Haplotype
Frequency
OR
rs3217986
C
1.03 (0.86–1.22)
rs3217986/rs523096
AC/CT/AT
0.48/0.08/0.44
1.05/1.05/0.95
0.31/0.61/0.22
rs523096
C
1.04 (0.95–1.14)
rs523096/rs10965215
CA/TA/CG/TG
0.03/0.40/0.46/0.12
0.83/0.97/1.06/0.98
0.23/0.53/0.24/0.76
rs10965215
A
0.96 (0.88–1.05)
rs10965215/rs564398
GG/AA/GA
0.46/0.42/0.12
1.05/0.96/0.98
0.29/0.36/0.82
rs564398
G
1.05 (0.96–1.15)
rs564398/rs1333034
AG/GA/AA
0.12/0.46/0.43
0.97/1.05/0.96
0.71/0.29/0.41
rs1333034
G
0.97 (0.84–1.12)
rs1333034/rs8181047
AA/GG/AG
0.34/0.11/0.55
1.02/0.98/1.00
0.76/0.74/0.97
rs8181047
A
1.01 (0.92–1.12)
rs8181047/rs10811647
GG/AC/GC
0.40/0.34/0.26
0.96/1.01/1.04
0.35/0.78/0.44
rs10811647
G
0.96 (0.87–1.05)
rs10811647/rs1333039
CG/GC/CC
0.44/0.40/0.17
1.04/0.96/1.01
0.44/0.36/0.86
rs1333039
G
1.04 (0.95–1.14)
rs1333039/rs16905599
CA/GG/CG
0.06/0.44/0.50
1.05/1.04/0.95
0.62/0.40/0.28
rs16905599
A
1.05 (0.87–1.26)
rs16905599/rs1333040
AC/GC/GT
0.06/0.39/0.56
1.03/1.00/0.99
0.78/0.99/0.86
rs1333040
C
1.00 (0.91–1.09)
rs1333040/rs10757278
CG/TG/CA/TA
0.04/0.44/0.40/0.12
1.06/0.96/1.00/1.09
0.66/0.42/0.92/0.24
rs10757278
G
0.97 (0.89–1.07)
rs10757278/rs10811658
GA/AA/GG/AG
0.16/0.14/0.32/0.38
0.89/0.94/1.04/1.06
0.10/0.42/0.49/0.28
rs10811658
A
0.92 (0.83–1.02)
rs10811658/rs10811659
AC/GC/AT/GT
0.19/0.03/0.11/0.67
0.93/0.98/0.95/1.08
0.20/0.87/0.49/0.11
rs10811659
C
0.93 (0.83–1.04)
rs10811659/rs10757282
TC/CT/TT
0.44/0.21/0.35
1.07/0.92/0.98
0.14/0.14/0.72
rs10757282
C
1.08 (0.99–1.18)
rs10757282/rs10811661
CT/TT/CC
0.16/0.28/0.56
1.19/0.93/0.89
rs10811661
C
0.89 (0.78–1.00)
rs10811661/rs1333051
CT/CA/TA
0.11/0.05/0.84
0.95/0.81/1.12
rs1333051
T
0.95 (0.82–1.10)
rs1333051/rs2065501
TA/AA/TC/AC
0.03/0.29/0.08/0.60
0.92/1.08/0.95/0.96
0.61/0.15/0.57/0.38
rs2065501
A
1.06 (0.96–1.17)
rs2065501/rs10757287
AT/CT/AA/CA
0.09/0.04/0.23/0.64
1.07/1.02/1.05/0.94
0.41/0.91/0.36/0.19
rs10757287
T
1.05 (0.92–1.21)
n/a
n/a
n/a
n/a
n/a
n/a
Association results for T2D from single and two-point haplotype analysis after correction for gender, age, and BMI. Top associated haplotype rs10757282 and rs10811661 is outlined.
