Zinc Transporters and Zinc Signaling: New Insights into Their Role in Type 2 Diabetes

Figure 1

The predicted membrane topologies of the zinc transporters ZIP/SLC39 and ZnT/SLC30. ZIP/SLC39 has eight predicted transmembrane domains (TMDs) and a large histidine-rich domain between TMD3 and TMD4. The predicted number of TMDs for ZnT/SLC30 is six, with a large histidine-rich region between TMD4 and TMD5. The direction of zinc flux in relation to the cytoplasm is shown. Figure was adapted from Eide (2006) [30] and the image was produced using Servier Medical Art: http://www.servier.com/.