Clinicopathological Risk Factors and Biochemical Predictors of Safe Discharge after Total Thyroidectomy and Central Compartment Node Dissection for Thyroid Cancer: A Prospective Study
Table 1
Univariate and multivariate clinicopathological risk factor analysis for the development of hypocalcemic symptoms.
Variables
Asymptomatic 472 (42.2%)
Symptomatic 345 (57.8%)
Univariate
Multivariate
OR (95% CI)
OR (95% CI)
Age
<45 years
99 (21.0%)
96 (27.8%)
Ref.
Ref.
≥45 years
373 (79.0%)
249 (72.2%)
0.69 (0.49~0.96)
0.025
0.84 (0.68~1.03)
0.096
Gender
Male
111 (23.5%)
36 (10.4%)
Ref.
Ref.
Female
361 (76.8%)
309 (89.6%)
2.63 (1.74~4.08)
<0.001
1.62 (1.30~2.02)
<0.001
Size
≤1 cm
287 (60.8%)
208 (60.3%)
Ref.
Ref.
>1 cm
185 (39.2%)
137 (39.7%)
1.02 (0.76~1.37)
0.885
1.02 (0.84~1.22)
0.870
Extent of CCND
Unilateral
228 (48.3%)
140 (40.6%)
Ref.
Ref.
Bilateral
244 (51.7%)
205 (59.4%)
1.36 (1.02~1.83)
0.033
1.16 (0.98~1.38)
0.080
Multifocality
Unifocal
268 (56.8%)
174 (50.4%)
Ref.
Ref.
Multifocal
149 (31.6%)
116 (33.6%)
1.2 (0.87~1.65)
0.269
1.11 (0.87~1.42)
0.400
Bilaterality
Unilateral
318 (67.4%)
211 (61.2%)
Ref.
Ref.
Bilateral
96 (20.3%)
66 (19.1%)
1.04 (0.71~1.50)
0.855
0.93 (0.70~1.23)
0.595
Perithyroidal extension
Absent
181 (38.3%)
127 (36.8%)
Ref.
Ref.
Present
291 (61.7%)
218 (63.2%)
1.07 (0.79~1.44)
0.662
0.97 (0.81~1.17)
0.767
N staging
pN0
285 (60.4%)
204 (59.1%)
Ref.
Ref.
pN1a
187 (39.6%)
141 (40.9%)
1.05 (0.79~1.41)
0.719
1.03 (0.87~1.24)
0.708
OR: odds ratio, CI: confidence interval, and Ref.: reference.
