Ghrelin’s Effects on Proinflammatory Cytokine Mediated Apoptosis and Their Impact on β-Cell Functionality

Figure 5

Ghrelin and cytokines’ effects on insulin secretion. Glucose stimulated insulin secretion (GSIS) by INS-1 (a) and rat islet (b) cultures incubated in absence (C, control) or presence of cytokines (CTK), ghrelin (GHR), or both (CTK + GHR) for 48 h. Values are expressed as the ratio of insulin secreted at a stimulatory glucose concentration (22 mM) to insulin secreted at a basal glucose concentration (5.5 mM) and represent means ± SEM of values from 4 independent experiments. ; between groups.

(a)

(b)