Research Article
The Effect of Long-Term Intranasal Serotonin Treatment on Metabolic Parameters and Hormonal Signaling in Rats with High-Fat Diet/Low-Dose Streptozotocin-Induced Type 2 Diabetes
Figure 5
The AC stimulating effects of agonists of monoaminergic (a) and peptidergic (b) receptors in the brain of diabetic and nondiabetic rats and the influence of IS treatment. (A): a—serotonin, b—EMD-386088, c—dopamine, d—norepinephrine, and e—isoproterenol (all were used at a concentration of 10−5 M); (B): a—α-MSH (10−7 M), b—THIQ (10−7 M), c—γ-MSH (10−7 M), d—relaxin (10−8 M), and e—PACAP-38 (10−6 M). The AC stimulating effect was expressed as hormone-induced increase of AC activity over the basal enzyme activity, pmol cAMP/min per mg of membrane protein. The data are presented as M SD. () The difference between Groups C0 and D0 is significant at , and (#, ##) the differences between Groups C0 and ND + SER or between Groups D0 and D + SER are significant at and , respectively.