The Effect of Long-Term Intranasal Serotonin Treatment on Metabolic Parameters and Hormonal Signaling in Rats with High-Fat Diet/Low-Dose Streptozotocin-Induced Type 2 Diabetes

Figure 6

The inhibiting effects of hormones on forskolin-stimulated AC activity in the brain of diabetic and nondiabetic rats with and without IS treatment. a—5-NOT, b—5-MeO-DMT, c—bromocriptine, d—norepinephrine (all were used at a concentration of 10⁻⁵ M), and e—somatostatin-14 (10⁻⁶ М). The AC stimulating effect of forskolin (10⁻⁵ M) in the absence of hormone is taken as 100%. The data are presented as M SD. () The difference between Groups C0 and D0 is significant at , and (#, ##) the difference between Groups C0 and ND + SER or between Groups D0 and D + SER is significant at and , respectively.