The Effect of Long-Term Intranasal Serotonin Treatment on Metabolic Parameters and Hormonal Signaling in Rats with High-Fat Diet/Low-Dose Streptozotocin-Induced Type 2 Diabetes

Figure 8

The AC inhibiting effects of norepinephrine and somatostatin in the myocardium of diabetic and nondiabetic rats with and without IS treatment. a—norepinephrine (10⁻⁵ M) and b—somatostatin-14 (10⁻⁶ М). The AC stimulating effect of forskolin (10⁻⁵ M) in the absence of hormone is taken as 100%. The data are presented as M SD. (, ) The difference between Groups C and D0 is significant at and , respectively, and (#) the difference between Groups C and ND + SER or between Groups D0 and D + SER is significant at .