Mechanism and Treatment Strategy of Osteoporosis after Transplantation

Figure 1

Effect of glucocorticoid excess on bone after transplantation. The atlas has indicated that glucocorticoid has direct and indirect pathway to mediate osteoporosis and inhibits bone formation after transplantation. The signal transduction pathway: some factors establish a bridge between osteoblast and osteoclast, like complement component 3a (C3a) and collagen triple helix repeat containing 1 (Cthrc1), but there are few literatures after organ transplantation. The upward arrows show promoting effect; the downward arrows show lessening or inhibitory effects.