Mechanism and Treatment Strategy of Osteoporosis after Transplantation

Figure 2

The protection mechanism against glucocorticoid-induced osteoporosis. MicroRNA-29a and microRNA-17/20a can inhibit osteoclastogenesis and promote osteoblast proliferation. Epimedium, which is the Chinese patent medicine, can antagonize the abnormal expressions of OPG and RANKL mRNA. The gene encoding TXNIP may increase the ratio of OPG/RANKL to downregulate osteoblast-mediated osteoclastogenesis. These potential protection mechanisms can prevent the progression of GIO and can provide a feasible and effective guidance to the treatment of osteoporosis after transplantation. The upward arrows show promoting effect; the downward arrows show lessening or inhibitory effects.