Mechanism and Treatment Strategy of Osteoporosis after Transplantation

Figure 3

Effect of the nonglucocorticoid immunosuppressant on bone. FK506 binding protein 5 (FKBP5) messenger RNA (mRNA) can promote osteoclast differentiation, involved in glucocorticoid-induced osteoporosis; the function of sirolimus (SRL) on bone should be more discussed. The dashed arrows show that the other nonglucocorticoid immunosuppressants may not influence bone formation and bone mass or are still being evaluated for their skeletal effects.