Efficacy of Subantimicrobial Dose Doxycycline for Moderate-to-Severe and Active Graves’ Orbitopathy
Table 2
Eye signs, Clinical Activity Score, and Graves’ orbitopathy-specific quality of life (GO-QoL) score at baseline and at 12 and 24 wk evaluation.
Variable
Baseline
Change at 12 wk
Change at 24 wk
value, trend over time/baseline versus 24 wk
Proptosis (mm)
21.19 ± 1.95
0.04 (−0.6; 0.67)
−0.59 (−1.34; 0.16)
0.26a
Improved (, %)
2 (18.2%)
2 (18.2%)
Unchanged
11 (81.8%)
11 (81.8%)
Deteriorated
0 (0%)
0 (0%)
Eyelid aperture (mm)
12.31 ± 2.32
−0.15 (−1.07; 0.76)
−1 (−2.24; 0.24)
0.13a
Improved (, %)
2 (15.4%)
6 (46.2%)
Unchanged
9 (69.2%)
5 (38.5%)
Deteriorated
2 (15.4%)
2 (15.4%)
Lid lag (mm)
1.62 ± 1.94
−0.54 (−1.54; 0.47)
−2.55 (−4.06; −1.03)
0.008a
Improved (, %)
5 (38.5%)
7 (53.8%)
Unchanged
6 (46.2%)
5 (38.5%)
Deteriorated
2 (15.4%)
1 (7.7%)
Clinical Activity Score
4 (3–5)
−1.07 ± 0.95
−1.82 ± 0.87
<0.0001b
Improved
4 (30.8%)
8 (61.5%)
Unchanged
9 (69.2%)
5 (38.5%)
Deteriorated
0 (0%)
0 (0%)
Soft tissue signs (, %)
0.044c
Absent
0 (0%)
7 (53.8%)
Minimal
4 (30.8%)
2 (15.4%)
Moderate
8 (61.5%)
2 (15.4%)
Severe
1 (7.7%)
2 (15.4%)
Diplopia (, %)
0.614c
Absent
3 (23.1%)
5 (38.5%)
Intermittent
2 (15.4%)
2 (15.4%)
Inconstant
3 (23.1%)
1 (7.7%)
Constant
5 (38.4%)
5 (38.5%)
Ocular motility
Elevation (degrees)
22.54 ± 13.07
0.69 (−1.06; 2.44)
4 (0.48; 7.52)
0.0496a
Depression (degrees)
45.85 ± 15.97
−0.38 (−2.95; 2.19)
−1.91 (−5.97; 2.15)
0.35a
Adduction (degrees)
41.62 ± 7.79
−1.64 (−4.10; 0.83)
−0.09 (−3.25; 3.07)
0.78a
Abduction (degrees)
37.31 ± 11.40
−1.00 (−4.17; 2.17)
−1.91 (−3.87; 0.05)
0.14a
GO-QoL score
Visual functioning score
61.99 ± 25.9
3.03 (−8.01; 14.07)
9.65 (−0.28; 19.57)
0.21a
Appearance score
46.17 ± 20.97
18.28 (7.77; 28.79)
21.59 (5.83; 37.35)
0.008a
These parameters were expressed on a continuous scale, and repeated-measures regression model was used to evaluate the 24 wk trend over time. bThis parameter was presented as median (25th to 75th percentiles), and a nonparametric approach (Jonckheere-Terpstra test) was adopted to assess the 24 wk trend over time. cThese parameters were presented as numbers, and Mann-Whitney test was employed to compare the difference between baseline and 24 wk.
