Clinical Study
Comparison of GnRH Agonist, GnRH Antagonist, and GnRH Antagonist Mild Protocol of Controlled Ovarian Hyperstimulation in Good Prognosis Patients
Table 1
The outcome of COH in terms of oocytes and embryos.
| | | COH protocol |
Statistical significance at P < 0.05 | | Mild protocol | GnRH antagonist protocol (GnRH-ant) | GnRH agonist protocol (GnRH-a) |
| | Oocyte aspirations | 166 | 1096 | 1111 | |
| | Average female age (years) | 31.8 ± 3.2 | 31.8 ± 3.4 | 32.0 ± 3.4 | / |
| | Baseline FSH (mIU/mL) | 6.4 ± 1.8 | 6.7 ± 2.1 | 6.9 ± 2.0 | / |
| | Oocytes (per cycle) | 1500 (9.0 ± 5.2) | 10249 (9.4 ± 5.0) | 12004 (10.8 ± 5.6) | P = 0.0001 (mild versus GnRH-a),
P < 0.0001 (GnRH-ant versus GnRH-a) |
| | Immature oocytes (%) | 240 (16.0%) | 1602 (15.6%) | 1687 (14.1%) | P = 0.0420 (mild versus GnRH-a),
P = 0.0010 (GnRH-ant versus GnRH-a) |
| | Fertilized oocytes, 2PN (%) | 865 (57.7%) | 5440 (53.1%) | 6235 (51.9%) | P = 0.0009 (mild versus GnRH-ant),
P < 0.0001 (mild versus GnRH-a) |
| | Embryos (%) | 845 (56.3%) | 5198 (50.7%) | 5968 (49.7%) | P < 0.0001 (mild versus GnRH-ant),
P < 0.0001 (mild versus GnRH-a) |
| | Embryos (per cycle) | 5.1 ± 3.7 | 4.7 ± 3.3 | 5.4 ± 3.5 | P < 0.0001 (GnRH-ant versus GnRH-a) |
| | Embryo transfers (%) | 151 (91.0%) | 1017 (92.8%) | 1006 (90.5%) | / |
| | Transferred embryos (per ET) | 1.6 ± 0.5 | 1.6 ± 0.5 | 1.7 ± 0.4 | P = 0.0022 (mild versus GnRH-a),
P < 0.0001 (GnRH-ant versus GnRH-a) |
| | Cycles with embryo freezing (%) | 50 (30.1%) | 317 (28.9%) | 210 (18.9%) | P = 0.0008 (mild versus GnRH-a),
P < 0.0001 (GnRH-ant versus GnRH-a) |
| | Frozen embryos (per cycle) | 0.8 ± 1.4 | 0.9 ± 1.8 | 0.5 ± 1.3 | P = 0.0243 (mild versus GnRH-a),
P < 0.0001 (GnRH-ant versus GnRH-a) |
| | OHSS | 0 | 4 | 12 | / |
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