Clinical Study
Comparison of GnRH Agonist, GnRH Antagonist, and GnRH Antagonist Mild Protocol of Controlled Ovarian Hyperstimulation in Good Prognosis Patients
Table 2
The outcome of COH in terms of pregnancies, miscarriages, and deliveries.
| | | COH protocol |
Statistical significance at P < 0.05 | | Mild protocol | GnRH antagonist protocol (GnRH-ant) | GnRH agonist protocol (GnRH-a) |
| | Pregnancies | 69 | 367 | 355 | |
| | Pregnancies (per cycle) | 41.6% |
33.5% | 32.0% | P = 0.0414 (mild versus GnRH-ant),
P = 0.0141 (mild versus GnRH-a) |
| | Pregnancies (per ET) | 45.7% | 36.1% | 35.3% | P = 0.0227 (mild versus GnRH-ant),
P = 0.0134 (mild versus GnRH-a) |
| | Miscarriages and ectopic pregnancies (per pregnancy) | 16 (23.2%) | 81 (22.1%) | 69 (19.4%) | / |
| | Biochemical pregnancies | 2 | 12 | 6 | / |
| | Live birth rate (per cycle) | 52 (31.3%) | 277 (25.3%) | 281 (25.3%) | / |
| | Twin deliveries | 21.2% (11/52) | 11.6% (32/277) | 18.5% (53/281) | P = 0.0163 (GnRH-ant versus GnRH-a) |
| | Live births after FET | 7 | 35 | 23 | / |
| | Cumulative live birth rate (per cycle) | 59 (35.6%) | 312 (28.5%) | 303 (27.3%) | P = 0.0275 (mild versus GnRH-a) |
| | Cumulative twin deliveries | 20.3% (12/59) | 13.1% (41/312) | 18.2% (55/303) | / |
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