Oral Administration of Oleuropein and Its Semisynthetic Peracetylated Derivative Prevents Hepatic Steatosis, Hyperinsulinemia, and Weight Gain in Mice Fed with High Fat Cafeteria Diet

Figure 2

Effects of Ole and Ac-Ole on liver weight and liver histology. (a) Liver weight was significantly reduced in mice fed with a caf diet supplemented with Ole or Ac-Ole. (b) Relative liver weight. (c) Hematoxylin and eosin staining of liver sections (10x magnification). The liver of mice CAF was rich in fat vacuoles (indicated by the arrow). (d) Quantification of steatosis was expressed as mean of percentage of vacuolated cells calculated for each mouse liver. Values are mean ± SD. and compared to STD; and compared to CAF.

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