Oral Administration of Oleuropein and Its Semisynthetic Peracetylated Derivative Prevents Hepatic Steatosis, Hyperinsulinemia, and Weight Gain in Mice Fed with High Fat Cafeteria Diet

Table 2

Effects of Ole and Ac-Ole on hematological parameters.

Parameter	Units	STD	CAF	OLE	Ac-OLE	Range
WBC	(10^3/mm^3)	2.4 ± 0.5	2.8 ± 0.8	3.8 ± 1.2	4.0 ± 1.0	2.3–7.7
RBC	(10^6/mm^3)	8.6 ± 1.1	9.6 ± 0.2	9.0 ± 0.3	9.3 ± 0.4	8.4–10.2
HGB	(g/dL)	13.4 ± 0.2	14.1 ± 0.5	12.4 ± 0.4	12.8 ± 0.4	12.6–14.6
HCT	(%)	41.9 ± 6.3	46.5 ± 2.1	43.7 ± 1.5	44.3 ± 2.1	41.9–49.9
MCV	(fL)	48.3 ± 1.2	48.3 ± 1.5	48.4 ± 1.1	47.4 ± 0.6	48.0–52.0
MCH	(pg)	14.6 ± 0.1	14.7 ± 0.4	13.8 ± 0.2	13.7 ± 0.1	14.3–15.3
MCHC	(%)	30.4 ± 0.7	30.4 ± 0.5	28.4 ± 0.4	29.0 ± 0.4	28.6–30.8
Platelets	(10^3/μL)	1183.2 ± 71.4	1097.0 ± 316.8	1170.2 ± 160.0	1041.2 ± 317.7	980–1390
Neutrophils	(%)	7.4 ± 1.8	13.1 ± 6.4	9.8 ± 1.8	11.4 ± 2.1	2–34
Lymphocytes	(%)	87.6 ± 1.1	81.4 ± 7.3	86.2 ± 2.3	80.9 ± 5.6	59–97
Monocytes	(%)	0.8 ± 0.2	1.4 ± 0.9	1.0 ± 0.2	1.3 ± 1.7	0–6
Eosinophils	(%)	1.6 ± 0.5	2.1 ± 0.8	1.4 ± 0.8	2.3 ± 1.4	0–2

Blood samples were collected at the end of treatments and analysed using Hematology Analyzer ADVIA 2120 (Siemens Healthcare Diagnostics s.r.l., Milan, Italy) to obtain hematology parameters. STD: mice fed with STD diet; CAF: mice fed with CAF diet; OLE = mice fed with CAF diet plus OLE at 0.037 mmol/kg/day; Ac-OLE: mice fed with CAF diet plus Ac-OLE at 0.025 mmol/kg/day. WBC: white blood cells; RBC: red blood cells; HGB: hemoglobin; HCT: hematocrit; MCV: mean corpuscular volume; MCH: mean corpuscular hemoglobin; MCHC: mean corpuscular hemoglobin concentration.