Mechanisms Linking Inflammation to Insulin Resistance

Figure 2

Inflammatory pathways linking inflammation to insulin resistance. Activation of JNK and NF-κB pathways causes serine kinase phosphorylation of IRS-1 or IRS-2, which may block insulin signaling and finally lead to the occurrence of IR. In addition, JNK and NF-κB pathways are involved in the production of proinflammatory cytokines which may in turn become activation stimuli of the pathways.