Long-Term Effect of Surgery in Graves’ Disease: 20 Years Experience in a Single Institution

Table 1

Clinical characteristics of Graves’ disease patients who underwent surgery during the study period.

Clinical characteristics	All		Subtotal thyroidectomy		Total thyroidectomy
	( = 350)		( = 254)		( = 96)
		%		%		%
Gender
Female	270	77.0%	185	72.8%	85	88.5%
Male	80	22.9%	69	27.2%	11	11.5%
Age at surgery (year): median, IQR^†	30	(24, 39)	28	(23, 34)	39	(31.3, 50)
Resected thyroid weight (gram): median, range	70.6	(12.0–361.0)	84.9	(13.8–361.0)	32.5	(12.0–160.0)
Follow-up duration after surgery (month): median, IQR^†	61	(24, 103.3)	57	(23, 107)	63.5	(28.3, 91.8)
Ophthalmopathy
No	259	74.0%	180	70.9%	79	82.3%
Yes	91	26.0%	74	29.1%	17	17.7%
Reasons for surgery
Resistance to ATD^‡	195	55.7%	179	70.5%	16	16.7%
Symptomatic large goiter	24	6.9%	22	8.7%	2	2.1%
Suspicious undetermined mass	21	6.0%	12	4.7%	9	9.4%
Suspicion of malignancy	67	19.1%	0		67	69.8%
Patient’s desire	33	9.4%	31	12.2%	2	2.1%
Others (not described)	10	2.90%	10	3.9%	0
Incidence of thyroid carcinoma presented	79	22.6%	5	2.0%	74	77.1%
Papillary thyroid carcinoma size (cm): median, range	0.83	(0.2–5.2)	0.38	(0.3–0.5)	0.88	(0.2–5.2)

IQR: interquartile range; ^‡ATD: antithyroid hormone drug.
All the thyroid carcinomas presented in Graves’ disease were papillary thyroid carcinomas.