|
| Study | Patients | PEI prevalence | Factors associated with PEI | Strengths | Limitations |
|
Hardt et al. 2002 [9]
(cross sectional-study) | 323 | Elastase <200 = 51%
Elastase <100 = 28.5% | (i) Association with diabetes duration, early onset, and insulin usage
(ii) No association with age and sex | (i) Large cohort of patients
(ii) Inclusion and exclusion criteria well designed | (i) Cross-sectional study without prospective evaluation of patients
(ii) Risk factors subgroup analysis not performed in DI and DII patients |
|
Larger et al. 2012 [10]
(cross-sectional study) | 195 | Elastase <200 = 34%
Elastase <100 = 19% | (i) Association with diabetes duration
(ii) No association with insulin dose, elevated BMI, age, and early age at onset | (i) Large cohort of patients
(ii) Risk factors subgroup analysis performed | (i) Cross-sectional study without prospective evaluation of patients
(ii) Patients with type III diabetes included
(iii) Inclusion and exclusion criteria not well specified |
|
Icks et al. 2001 [11]
(cross-sectional study) | 112 | Elastase < 200 = 45.5%
Elastase < 100 = 25.9% | (i) Association with male sex and age
(ii) No association with diabetes duration, elevated BMI, early age at diabetes onset, and smoke or alcohol usage | (i) Specifically performed on type I diabetes patients
(ii) Case-control study
(iii) Risk factors specifically and extensively evaluated | (i) Relatively small number of patients
(ii) Cross-sectional study without prospective evaluation of patients |
|
Cavalot et al. 2006 [12]
(cross-sectional study) | 66 | Elastase < 200 = 25.8%
Elastase < 100 = 10.6% | (i) No association with age, diabetes duration, elevated HbA1c, early age at diabetes onset, and elevated BMI | (i) Specifically performed on type I diabetes patients
(ii) Extensive analysis on PEI-related clinical symptoms | (i) Small number of patients
(ii) Cross-sectional study without prospective evaluation of patients |
|
Vujasinovic et al. 2013 [13]
(cross-sectional study) | 50 | Elastase < 200 = 6%
Elastase < 100 = 2% | (i) No association with diabetes duration | (i) Extensive analysis on PEI-related clinical symptoms
(ii) MRI with MRCP performed in all diabetic patients with PEI | (i) Small number of patients
(ii) Enrollment criteria not well-defined
(iii) Cross-sectional study without prospective evaluation of patients defined
(iv) Poor risk factors analysis |
|
Hahn et al. 2008 [14]
(cross-sectional study) | 33 | Elastase < 200 = 27.3% | (i) No association with sex, age, diabetes duration, elevated HbA1c, early age at diabetes onset, and elevated BMI | (i) All patients underwent both SCT and indirect tests to assess PEI | (i) Very small number of patients
(ii) Cross-sectional study without prospective evaluation of patients defined |
|
Hardt et al. 2000 [15]
(cross-sectional study) | 31 | Elastase < 200 = 56.7%
Elastase < 100 = 30% | (i) Association with GI symptoms
(ii) No association with diabetes duration and alcohol usage | | (i) Very small number of patients
(ii) Enrollment criteria not well-defined
(iii) Cross-sectional study without prospective evaluation of patients defined
(iv) No subgroup analysis performed for DI and DII |
|
