The Associations of Novel Vitamin D₃ Metabolic Gene CYP27A1 Polymorphism, Adiponectin/Leptin Ratio, and Metabolic Syndrome in Middle-Aged Taiwanese Males

Table 1

Means ± standard deviations or numbers (%) of the baseline characteristics and biochemical variables in the patients with the CYP27A1 rs4674344 SNP.

	Subjects with AA ()	Subjects with T-carrier ()	value
Age (yr)	55.5 ± 4.1	56.1 ± 5.1	0.11
BMI (kg/m^2)	25.6 ± 7.1	25.6 ± 2.9	0.93
Waist circumference (cm)	85.7 ± 7.2	87.1 ± 6.9	0.03^*
Hip circumference (cm)	100.4 ± 64.5	97.8 ± 5.5	0.57
SBP (mm-Hg)	130.9 ± 12.4	130.5 ± 11.1	0.75
DBP (mm-Hg)	82.1 ± 8.6	82.3 ± 8.7	0.86
DM, (%)	4.2 (9.4)	27 (13.4)	0.14
Hypertension, (%)	124 (27.7)	66 (32.7)	0.20
Smoking, (%)			0.36
Nonsmokers	331 (74.0)	140 (69.3)
Former smokers	62 (13.9)	30 (14.9)
Current smokers	54 (12.1)	32 (15.8)
Dyslipidemia history, (%)	76 (16.8)	53 (26.2)	0.006^*
CAD history, (%)	30 (6.7)	15 (7.4)	0.76
Stroke history, (%)	3 (0.7)	5 (2.5)	0.056
Betel quid, (%)	2 (0.4)	1 (0.5)	0.87
Blood biochemistry
Fasting glucose (mg/dL)	99.6 ± 20.6	101.2 ± 22.2	0.36
Triglycerides (mg/L)	134.1 ± 98.6	137.7 ± 88.8	0.66
Total cholesterol (mg/dl)	188.6 ± 33.4	191.9 ± 35.8	0.25
HDL-C (mg/dL)	48.5 ± 11.0	46.5 ± 11.3	0.04^*
CHOL(T)/HDL	4.1 ± 1.0	4.3 ± 1.0	0.006^*
Adiponectin (ng/mL)	12.1 ± 7.2	10.9 ± 6.2	0.03^*
Leptin (ng/mL)	4.0 ± 3.3	6.5 ± 28.2	0.005^*
Adiponectin/leptin	5.1 ± 6.0	3.7 ± 4.0	0.001^*
1,25(OH)2D3 (pg/mL)	45.6 ± 19.0	43.3 ± 17.2	0.14

BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; DM: diabetes mellitus; CAD: coronary artery disease; CHOL(T): total cholesterol; HDL: high density lipoprotein. Significant difference ().