The Associations of Novel Vitamin D3 Metabolic Gene CYP27A1 Polymorphism, Adiponectin/Leptin Ratio, and Metabolic Syndrome in Middle-Aged Taiwanese Males
Table 1
Means ± standard deviations or numbers (%) of the baseline characteristics and biochemical variables in the patients with the CYP27A1 rs4674344 SNP.
Subjects with AA ()
Subjects with T-carrier ()
value
Age (yr)
55.5 ± 4.1
56.1 ± 5.1
0.11
BMI (kg/m2)
25.6 ± 7.1
25.6 ± 2.9
0.93
Waist circumference (cm)
85.7 ± 7.2
87.1 ± 6.9
0.03*
Hip circumference (cm)
100.4 ± 64.5
97.8 ± 5.5
0.57
SBP (mm-Hg)
130.9 ± 12.4
130.5 ± 11.1
0.75
DBP (mm-Hg)
82.1 ± 8.6
82.3 ± 8.7
0.86
DM, (%)
4.2 (9.4)
27 (13.4)
0.14
Hypertension, (%)
124 (27.7)
66 (32.7)
0.20
Smoking, (%)
0.36
Nonsmokers
331 (74.0)
140 (69.3)
Former smokers
62 (13.9)
30 (14.9)
Current smokers
54 (12.1)
32 (15.8)
Dyslipidemia history, (%)
76 (16.8)
53 (26.2)
0.006*
CAD history, (%)
30 (6.7)
15 (7.4)
0.76
Stroke history, (%)
3 (0.7)
5 (2.5)
0.056
Betel quid, (%)
2 (0.4)
1 (0.5)
0.87
Blood biochemistry
Fasting glucose (mg/dL)
99.6 ± 20.6
101.2 ± 22.2
0.36
Triglycerides (mg/L)
134.1 ± 98.6
137.7 ± 88.8
0.66
Total cholesterol (mg/dl)
188.6 ± 33.4
191.9 ± 35.8
0.25
HDL-C (mg/dL)
48.5 ± 11.0
46.5 ± 11.3
0.04*
CHOL(T)/HDL
4.1 ± 1.0
4.3 ± 1.0
0.006*
Adiponectin (ng/mL)
12.1 ± 7.2
10.9 ± 6.2
0.03*
Leptin (ng/mL)
4.0 ± 3.3
6.5 ± 28.2
0.005*
Adiponectin/leptin
5.1 ± 6.0
3.7 ± 4.0
0.001*
1,25(OH)2D3 (pg/mL)
45.6 ± 19.0
43.3 ± 17.2
0.14
BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; DM: diabetes mellitus; CAD: coronary artery disease; CHOL(T): total cholesterol; HDL: high density lipoprotein. Significant difference ().